Within the four-year timespan of the IN SITU project, dedicated to place-based innovation of cultural and creative industries (CCIs) in non-urban areas, two research streams focused their work, separately, on innovation policy and on cultural policy. Both streams are now coming together through a cross-analysis of both policy areas and research findings, leading to this combined policy handbook for CCIs in non-urban areas. It is designed to inform policymakers, CCI actors, and administrators involved in the organisation of culture and to foster a dialogue between those actors.